RNA interference-mediated downregulation of Beclin1 attenuates cerebral ischemic injury in rats
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Adenoviruses-mediated RNA interference targeting cytosolic phospholipase A2α attenuates focal ischemic brain damage in mice
Cerebral ischemia injury is a clinical, frequently occurring disease, which causes a heavy burden on society and families. It has been demonstrated that cytosolic phospholipase A2α (cPLA2α) is significant in neurological injury caused by ischemic brain injury, and inhibition of cPLA2α may reduce stroke injury. In the present study, the role of cPLA2α was investigated in a mouse model of middle ...
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Tamiji Tsubokawa, Vikram Jadhav, Ihsan Solaroglu, Yoshiaki Shiokawa, Yoshifumi Konishi Ischemic Injury via Antiapoptotic Mechanisms in Rats Lecithinized Superoxide Dismutase Improves Outcomes and Attenuates Focal Cerebral Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2007 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Green...
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BACKGROUND AND PURPOSE Recent studies have shown the antiapoptotic neuroprotective effects of lecithinized superoxide dismutase (PC-SOD) in different forms of brain injury. We tested the effects of PC-SOD in focal cerebral ischemia in the rat middle cerebral artery occlusion model (MCAO). METHODS Adult male Sprague-Dawley rats were treated with PC-SOD (0.3, 1.0, and 3.0 mg/kg) administered in...
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The Src homology domain 2 (SH2)-containing tyrosine phosphatase-1 (SHP-1) plays a key role in apoptosis and decreases phosphorylation of Akt. Apoptosis of cardiomyocytes is thought to contribute to the increased area of acute myocardial infarction (AMI), and Akt activation exerts a powerful cardioprotective effect after ischemia. Thus, a therapeutic strategy designed to inhibit expression of SH...
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ژورنال
عنوان ژورنال: Acta Pharmacologica Sinica
سال: 2009
ISSN: 1671-4083,1745-7254
DOI: 10.1038/aps.2009.79